Monitoring of benzodiazepines (clobazam, diazepam and their main active metabolites) in human plasma by column-switching high-performance liquid chromatography.
Identifieur interne : 001475 ( France/Analysis ); précédent : 001474; suivant : 001476Monitoring of benzodiazepines (clobazam, diazepam and their main active metabolites) in human plasma by column-switching high-performance liquid chromatography.
Auteurs : C. Lacroix [France] ; F. Wojciechowski ; P. DangerSource :
- Journal of chromatography ; 1993.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Anti-Anxiety Agents, Benzodiazepinones, Diazepam.
- chemical , metabolism : Anti-Anxiety Agents.
- chemical : Benzodiazepines.
- methods : Chromatography, High Pressure Liquid.
- Chromatography, Gel, Humans, Reproducibility of Results, Spectrophotometry, Ultraviolet.
Abstract
A column-switching high-performance liquid chromatographic method for the simultaneous determination of clobazam, diazepam and their main metabolites in human plasma is described. A 200-microliters plasma sample was directly injected into a precolumn filled with TSK-gel PW. After a washing step with potassium phosphate buffer, the retained substances were backflushed into a reversed-phase column with a mobile phase of acetonitrile-phosphate buffer-diethylamine. Various drugs frequently co-administered with clobazam or diazepam do not interfere with the determination.
PubMed: 8104951
Affiliations:
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pubmed:8104951Le document en format XML
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Danger</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1993">1993</date><idno type="RBID">pubmed:8104951</idno><idno type="pmid">8104951</idno><idno type="wicri:Area/PubMed/Corpus">000428</idno><idno type="wicri:Area/PubMed/Curation">000428</idno><idno type="wicri:Area/PubMed/Checkpoint">000428</idno><idno type="wicri:Area/Ncbi/Merge">000609</idno><idno type="wicri:Area/Ncbi/Curation">000609</idno><idno type="wicri:Area/Ncbi/Checkpoint">000609</idno><idno type="wicri:Area/Main/Merge">002259</idno><idno type="wicri:Area/Main/Curation">002194</idno><idno type="wicri:Area/Main/Exploration">002194</idno><idno type="wicri:Area/France/Extraction">001475</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Monitoring of benzodiazepines (clobazam, diazepam and their main active metabolites) in human plasma by column-switching high-performance liquid chromatography.</title><author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Pharmacocinétique, Centre Hospitalier, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacocinétique, Centre Hospitalier, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Wojciechowski, F" sort="Wojciechowski, F" uniqKey="Wojciechowski F" first="F" last="Wojciechowski">F. Wojciechowski</name></author><author><name sortKey="Danger, P" sort="Danger, P" uniqKey="Danger P" first="P" last="Danger">P. Danger</name></author></analytic><series><title level="j">Journal of chromatography</title><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Anxiety Agents (blood)</term><term>Anti-Anxiety Agents (metabolism)</term><term>Benzodiazepines</term><term>Benzodiazepinones (blood)</term><term>Chromatography, Gel</term><term>Chromatography, High Pressure Liquid (methods)</term><term>Diazepam (blood)</term><term>Humans</term><term>Reproducibility of Results</term><term>Spectrophotometry, Ultraviolet</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Anti-Anxiety Agents</term><term>Benzodiazepinones</term><term>Diazepam</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Anti-Anxiety Agents</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Benzodiazepines</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, High Pressure Liquid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chromatography, Gel</term><term>Humans</term><term>Reproducibility of Results</term><term>Spectrophotometry, Ultraviolet</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A column-switching high-performance liquid chromatographic method for the simultaneous determination of clobazam, diazepam and their main metabolites in human plasma is described. A 200-microliters plasma sample was directly injected into a precolumn filled with TSK-gel PW. After a washing step with potassium phosphate buffer, the retained substances were backflushed into a reversed-phase column with a mobile phase of acetonitrile-phosphate buffer-diethylamine. Various drugs frequently co-administered with clobazam or diazepam do not interfere with the determination.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Le Havre</li></settlement></list><tree><noCountry><name sortKey="Danger, P" sort="Danger, P" uniqKey="Danger P" first="P" last="Danger">P. Danger</name><name sortKey="Wojciechowski, F" sort="Wojciechowski, F" uniqKey="Wojciechowski F" first="F" last="Wojciechowski">F. Wojciechowski</name></noCountry><country name="France"><noRegion><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. 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